Luciano Milanesi is the Head of the Bioinformatics Group at National Research Council (CNR) - Institute of Biomedical Technology. He has been working and published since 1986 in the field of Bioinformatics and System Biology and Medical Informatics to develop new methods applied to the human genome analysis. He is Director the Flagship "InterOmics" project of the Ministry of Education, Universities and Research (Italy).

He is actually involved in the Common Service ICT, of the BBMRI-ERIC a Biobanks and biomolecular research infrastructure European consortium; ELIXIR a distributed infrastructure for life life-science information and responsible for the Italian national node of INCF of the international non-profit organization devoted to advancing the field of Neuroinformatics. He is a founder of the Bioinformatics Italian Society (BITS) and System Biology for Health Society (SYSBIO-HEATH).
He is the author of more than 300 publications in the field of Bioinformatics, Systems Biology and Medical Informatics.